Take On the Colon Cancer

Colon cancer is the third most common cancer in incidence and mortality worldwide (Fearon et al., 1990), and one of the few cancers that can be prevented. Fortunately, this disease often starts from the beginning with abdominal pain and symptoms. 

Less than 10% of patients in stage I disease recurrence and does not benefit for whom adjuvant chemotherapy, 20% of patients in stage II disease have a recurrence and for whom adjuvant chemotherapy minimal benefit (Marshall, 2010) because in the early stages of colon cancer (stages I and II) tumor engulfed all the inner walls of the colon. In stage III colon cancer there are regional lymph node metastases and the administration of adjuvant chemotherapy have been seen a significant increase in survival (Meyerhardt et al., 2005). In stage IV colon cancer patients are with distant metastases, tougher regimes in the process of receiving treatment that is not common treatments (Boland et al., 2016).

Literature review on Bio degradable Nano spheres for Oral and Targeted Drug Delivery

Nano sphere systems have great potentials, being able to convert poorly soluble, poorly absorbed and labile biologically active substance into promising deliverable drugs. The core of this system can enclose a variety of drugs, enzymes, genes and is characterized by a long circulation time due to the hydrophilic shell which prevents recognition by the reticular-endothelial system. To optimize this drug delivery system, greater understanding of the different mechanisms of biological interactions, and particle engineering, is still required. Further advances are needed in order to turn the concept of nanoparticles technology into a realistic practical application as the next generation of drug delivery system.